My experiences with larium were depression, sleeplessness, feelings of uselessness and persecution, bordering on the suicidal. I think taking it in any proximity with psychoactive drugs (mushrooms in my case) is a mistake. I have taken it and been fine in the past, but after my experience last year I won´t again. I think it varies from person to person and time to time. My normal 14 year old mind had no problems with it, but at 22, my mind had a few more substances floating around in it and a few more crossed wires which didn´t like the Larium at all...